HuskinDB, a database for skin permeation of xenobiotics
نویسندگان
چکیده
منابع مشابه
Influence of Chemical Permeation Enhancers on the in vitro Skin Permeation of Minoxidil through Excised Rat Skin: A Mechanistic Study
Abstract: Minoxidil, a pyrimidine derivative (2, 4-diamino-6-piperidinopyrimidine-3-oxide) is the only topical medical treatment with proven efficacy for the treatment of Androgenetic alopecia that shown low skin penetration and bioavailability. The main aim of this research was to investigate the effect of some permeation enhancers on the in vitro skin permeability of minoxidil . Minoxid...
متن کاملThe Transformer database: biotransformation of xenobiotics
As the number of prescribed drugs is constantly rising, drug-drug interactions are an important issue. The simultaneous administration of several drugs can cause severe adverse effects based on interactions with the same metabolizing enzyme(s). The Transformer database (http://bioinformatics.charite.de/transformer) contains integrated information on the three phases of biotransformation (modifi...
متن کاملSkin preparation and permeation experiments
First, excised human skin obtained from abdominal plastic surgery is prepared for storage. In this procedure, the subcutaneous fatty tissue is separated from the outer skin layers, namely the epidermis and the dermis by a scalpel. Second, the epidermis is separated from the underlying dermis by a heat-separation technique. The separated epidermis will be used for subsequent permeation experimen...
متن کاملA Database Model for Medical Consultation
The database model presented in this paper is suitable for application in which queries may require non-crisp references to certain attributes. The data item (attribute) values may be crisp or fuzzy. For instance, such adjectives as 'high' or 'normal' may be attribute values for the attribute blood pressure. A disease or a condition can be described by a number of symptoms which may be crisp al...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Data
سال: 2020
ISSN: 2052-4463
DOI: 10.1038/s41597-020-00764-z